202211201931
Status:
Tags: Psychiatry
Modeling
- Hyperdopaminergia induces hyperlocomotion & disrupts prepulse inhibition (PPI) in mice
- Haloperidol induces catalepsy in mice (inhibition of dopamine system)
- Inhibition of hyperlocomotion, reversal of disrupted PPI, and cataleptic potential are commonly used to test efficacy of antipsychotics
- Induction of catalepsy is used to test extrapyramidal symptoms of antipsychotics