DHA

Part of Omega-3 fatty acids

Inhibits nuclear factor kappa B which mediates cytokines

Increases levels of glutathione by regulating degradation of I$\kappa$B, which normally binds to NF-$\kappa$B.

Activates peroxisome proliferator activated receptor (PPAR-y)

• Agonism decreases induction of Cytokines

DHA in neurons! Bound to phospholipids. During tissue stress, DHA is released and oxidised into resolvins and protectins

• Resolvins downregulate NF-$\kappa$B expression
• Protectins regulate IL-1$\beta$ mediated stimulation of cyclooxygenase (Bradbury 2011)

During neuronal activation

• DHA released into cytosol
• Small portion converted to neuroprotectin (Green2008)

DHA correlated with BDNF levels

Catalyzes tyrosine hydroxylase

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Related

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