Psychedelics act on the 5-HT2a receptor
202308031917
Status:
Tags: psychedelic 5-HT2a
- partial agonism of 5-HT2a receptor accounts for primary subjective & neural effects of serotonergic psychedelics Nichols2016 Kwan2022
- This property has been most consistently established via antagonist pretreatment studies, which block the hallucinogenic effect of psychedelics Vollenweider1998 Kraehenmann2017 Valle2016 Deco2018
Ketanserin blocks the subjective effects of psychedelics
psychedelic 5-HT2a agonists stimulate expression of immediate early genes that encode transcription factors including c-fos Frankel2002, egr-1 and egr-2 Gonzalez-Maeso2007, BDNF Gewirtz2002
- Activation of these factors is associated with synaptic plasticity ODonovan1999 & memory Jones2001 & attention DeSteno2008
Related Notes
5-HT2a receptors are densely expressed in the cortex
5-HT2a agonism induces asynchronous glutamate release
5-HT2a receptors increase GABAergic transmissionz