Psychedelics in predictive processing
202308041500
Pink-Hashkes et al. proposed that ‘decomposed’ high-level priors under psychedelics encourages the slippage of prediction error that is processed at a more granular level than would ordinarily be the case: accounting for the unusual perceptual/cognitive changes characteristic of psychedelic experiences Pink-Hashkes2017.
As 5-HT2a receptors are densely expressed in the cortex, Layer V Pyramidal Neurons are cortical information-integration units, and Psychedelics decrease oscillatory power across frequency bands, it is thought that Cortical rhythms carry priors via predictive processing.
Proposed previously by a few papers: Muthukumaraswamy2013, Timmermann2017, Carhart-Harris2010.