Oleamide
Summary
Appears to help with sleep quality & onset
100-200mg nightly
Pharmacology
- Interacts with GABA receptors.
- Binds to CB1
- Promotes healthy levels of inflammation via CB2
- Makes 5-HT2a, 5-HT1a, 5-HT2c receptors more sensitive
- Inhibits 5-HT7
- Primary amide derivative of oleic acid
- Structurally similar to anandamide (endogenous cannabinoid ligand)
- First isolated from spinal fluid of sleep-deprived cats
- Classified as fatty acid primary amide (FAPA) & occurs naturally, accumulates in CSF during sleep deprivation
- Used in TCM for sleep support
- Jujube fruit (dates back 2500 years)