dihydromyricetin
Summary
300mg before drinking will reduce effects of alcohol.
Increase in mental clarity, sharpness, anxiolysis
Slight dizziness at 300mg
pharmacology
Prevents doxorubicin-induced cardiotoxicity
Improves glucose and lipi dmetabolism
Anti-inflammatory, anti-carcinogenic, ROS scavenging, anti-bacterial, anti-apoptotic mechanisms
Regulates AMPK, MAPK, Akt, NF-kappaB, Nrf2, ABCA1, PPARy
Improves insulin sensitivity
Decreases miRNAs involved in aging-related disease
Upregulates SIRT1, p53/p21, downregulates mTOR via miR-34a
Inhibits COMT and restores behavioral impairments from MPTP
Reduced immobility time in TST and FST
Preserves memory, synaptic structure of HIPP neurons, promotes mitochondrial biogenesis, decreases lipid peroxidation, suppress ROS generation in hypobaric hypoxia-trated rats
Antagonize effects of alcohol while enhancing GABAa function (competes with ethanol for GABAa)
Flavonol