202211201924
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Tags:
Consolidation & Retrieval
With context to Place and Grid Cells
- Stage in which memory is encoded via weak synaptic potentiation in CA3 when network is in theta-oscillation mode during exploratory behavior
- Memory consolidation stage which takes place hours later during sharp-wave activity, associated with sleep and resting
- Synapses that are weakly potentiated during preceding exploration participate in sharp-wave activity in CA1
- Ripples occur at frequency optimal for induction of LTP in efferent synapses of CA1 cells
By this mechanism, memory is thought to be slowly induced in neocortex, consistent with evidence pointing to gradual recruitment of neocortical memory circuits in long-term storage of hippocampal memories.
Evidence for
- Selective disruption of sharp-wave ripple activity during posttraining rest periods impairs learnin
- Sequences of firing are replayed during subsequent sharp-wave ripples in same or reverse order that cells were active during experience