Inflammasomes
202211201936
Status:
Tags: Immunology
Inflammasomes are cytosolic (living in cellular cyotosol) protein complexes that form myeloid cells in response to pathogens or non-pathogenic stress (e.g. DAMPs). Inflammasomes assemble → activate caspae 1 → cleaves precursor forms of cytokines IL-1B and IL-18 into active cytokines.
- Chronic mild stress activates NLRP3 inflammasome, which responds to DAMPs. Blocking NLRP3 reverses stress-induced increases in IL-1B in peripheral blood and brain, and reverses depression-like behavior in mice.
- NLRP3 upregulation & caspase-mediated cleavage of GRs can cause resistance to Glucocorticoids.