Psychedelic effects rely on disinhibition of lower-order systems
Convergent evidence and theories indicates that the subjective effects of psychedelics rely on the disinhibition of “lower” or evolutionarily earlier systems, such as the limbic system.
Evidence from multiple studies indicates this is true:
- Timmermann2023 →
- Preller2019 → LSD increases effective connectivity from the thalamus to PCC