BOLD
202308161903
Measures local fluctuations in deoxyhemoglobin through the Hemodynamic response function.
It’s controversial what this actually represents:
Viswanathan2007 (Review: Nichols2016)
- Cerebral vasoconstrictors can cause an increase in deoxyhemoglobin concentrations, resulting in a decrease in the BOLD baseline resting signal Mulderink2002
- Hemodynamic neuroimaging signals as proxy measures for neuronal activity invites off-target effects, such as peripheral actions mediated by other receptor subtypes you’re not interested in