202211201900
Status:
Tags: Neurotransmitters
- One of the major catecholamine neurotransmitters in the mammalian brain
- Regulates movement, reward, cognition, emotion
Experimental techniques
Reduction in [C]raclopride binding potential has been established a measure of change in synaptic DA concentration in animal and human studies Vollenweider2001b
Dysfunction
Dysfunction of DA neurotransmission associated with schizophrenia, ADHD, Parkinson, and Tourette syndromes.
Mechanisms
- Binds to and activates GPCRs of two subclasses: D1 (D1R, D5R) and D2 (D2R, D3R, D4R), the highest expression being in the striatum
- G-protein-dependent cyclic AMP/protein kinase A/dopamine, cyclic AMP-regulated phosphoprotein of 32 kDa (cAMP/PKA/DARPP32) pathway
- Signaling downstream of DA D2 receptor activation → mediated by beta-arrestin 2 (Barr2) dependent signaling complex; Barr2/protein kinase B (Akt)/protein phosphotase 2A (PP2A) → activation of glycogen synthase kinase 3 beta (GSK3B)
- Disrupted by Lithium
- GSK3B and D2Rs required to form this complex