Psychedelics increase glucose metabolism and cerebral blood flow

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Vollenweider1997 PET, increase in glucose metabolism with [18F]-FDG PET

Riba2006 increase in SPECT in bilateral anterior insula and inferior frontal gyrus, greater activity in right hemisphere

Hermle1992 increase in activation of frontal regions

Gouzoulis-Mayfrank1999 highest increases in [18F]-FDG PET psilocybin in ACC and right frontal operculum.