EPA

One of the Omega-3 fatty acids

In the brain

Inhibits delta-5-desaturase (D5D) which synthesizes $\omega$-6-PUFA arachidonic acid (AA)

• AA is pro-inflammatory

Produces resolvins when it binds to COX and lipoxygnease (LOX)

• COX and LOX convert AA to pro-inflammatory metabolites
• EPA competes with AA for COX/LOX

Increases serotonin somehow

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Related

References