Psychedelics suppress the default mode network
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Psychedelics have been shown to suppress the default mode network Buckner2008 (Review: Nichols2016)
- Correlates with Psychedelics decrease BOLD activity
- Significant decrease in positive coupling between mPFC and PCC (two key hubs of the DMN) Carhart-Harris2012
- Decoupling between DMN and medial temporal lobes during psychedelics (Carhart-Harris2014)