The paradox between decreased irreversibility and decreased structural-functional similarity under psychedelics
202309151804
Bayesian structural-functional similarity indicates that Psychedelics decrease structural-functional similarity under high network segregation by increasing the weight of incoming information and decreasing the influence of structural priors on patterns of functional connectivity.
- Consistent with REBUS
This lies in contrast to results on irreversibility, which indicate that Psychedelics (LSD, DMT, ayahuasca) decrease irreversibility, in turn decreasing the weighting of external information.
Resolving this paradox may lie in looking closer at dynamic functional connectivity and dynamic irreversibility.