Psychedelics Decrease structural-functional similarity under high network segregation

202309151445


Luppi2021

No significant changes were found for time-averaged FC or in a predominantly integrated sub-state (brain integration and segregation), where integration is when ROIs participate more with their RSNs than others, but in a predominantly segregated state, structural-functional similarity was found to be significantly decreased under LSD (Luppi2021).

  • Same results with both implementations of structural-functional similarity

The highest structural-functional similarity was found in the predominantly integrated sub-state (Luppi2021), in line with Fukushima2018.

Structural-functional similarity corresponds to states of consciousness, and Structural-functional similarity increases under anesthesia.


Psychedelics suppress anticorrelations between brain regions
Loss of consciousness suppresses anticorrelations between brain regions


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