Psychedelics increase striatal dopamine
202308231140
ketamine and psilocybin reduce []raclopride BP in ventral striatum consistent with increase in striatal DA concentration (Vollenweider2001b)
- Significantly correlated with depersonalization, consistent with view that excessive DA transmission at D2 contributes to generation of positive psychotic symptoms in ketamine and psilocybin.
- Only explains 36% of variance in positive psychotic symptoms
- Application of haloperidol (D2 antagonist) has virtually no effect on psilocybin-induced cognitive impairment
- Ketamine psychosis is not ameliorated by haloperidol pre-treatment