202211201923
Status:
Tags: Neuroplasticity

Long-term potentiation

High-frequency stimulation depolarizes the neuron through AMPA, releases Mg2+ block from NMDA and allows Ca2+ into the cell. This initiates a signal cascade with CaMKII that results in the exocytosis of AMPA receptors, resulting in stronger EPSPs/postsynaptic stimulation

How does the neuron decide which to do?

• Magnitude of calcium signal
  • When Ca2+ entry is below threshold, it leads to LTD