Psychedelics and ketamine produce deficits in PPI
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See title. Prepulse inhibition Vollenweider2001b
M100,907 (5-HT2a antagonist), but not 5-HT2C antagonists, block disruption of PPI in rats by Psychedelics (Vollenweider2001b)
Effects of Psychedelics on sensorimotor gating in rats are mediated in part by 5-HT2a receptors in the ventral globus pallidus, a component of the CSTP loop.
- Antagonist action at 5-HT2a may have an important contribution to efficacy of atypical antipsychotics like clozapine in treatment of schizophrenia. (Vollenweider2001b)