Psychedelics disrupt information processing in CSTC loops
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CSTC feedback loops are implicated in sensory and sensorimotor gating. Psychedelics impair sensorimotor gating. Vollenweider2001b Geyer2008.
Psychedelics alter thalamocortical (thalamus-cortex) transmission through stimulation of 5-HT2a receptors located in key components of CSTC loops Vollenweider2007 Geyer2008.
- Psychedelic neuroimaging
- psychedelics induce hyperfrontality, alter activity in basal ganglia and thalamus Hermle1992 Hermle1998 Gouzoulis-Mayfrank1999 Riba2006 and this correlates with different dimensions of psychedelic states Vollenweider2001b (Review: Nichols2016)