MDMA
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MDMA moderately increased brain activity in PET with [HO]-PET as indexed by CBF in ventromedial PFC, ventral ACC, inferior temporal cortex, medial occipital cortex, and cerebellum (Vollenweider2001b)
- Decreases found bilaterally in motor cortex and somatosensory cortex, superior temporal cortex, dorsal ACC, insula, thalamus.
- Unilateral decreases in left amygdala and right parahippocampus
Moderate affinity for 5-HT2 receptors, alpha2, and DA receptors Vollenweider2001b
Pretreatment with SSRIs citalopram reduced all psychological effects of MDMA in healthy volunteers Vollenweider2001b.
D2 antagonist haloperidol only partly reduced euphoric effects of MDMA suggesting that dopamine contributes little to psychological effects of MDMA Vollenweider2001b.
MDMA disrupts sensorimotor gating as indexed by PPI in rats but increases PPI in humans (Vollenweider2001b).
Increase in social communication (“extroversion” subscale of Adjective Mood Rating Scale) correlates with CBF in temporal cortex, amygdala, OFC (Vollenweider2001b)
- These regions form the basolateral circuit