Psychedelics decrease oscillatory power across frequency bands
Psychedelics decrease oscillatory power across frequency bands
Because 5-HT2a receptors are densely expressed in the cortex, 5-HT2a agonism results in dysregulation of population-level oscillatory rhythms including alpha and beta frequency bands Muthukumaraswamy2013.
- LSD, psilocybin, and ayahuasca induce decreases in -power (Muthukumaraswamy2013, Kometer2013, Valle2016, Kometer2015)
- Closely related to subjective effects (Muthukumaraswamy2013, Carhart-Harris2016)
Celada2008 showed DOI markedly reduces amplitude of low frequency oscillations in the mPFC, thereby disrupting cortical activity. Furthermore, the authors found that DOI desynchronized Pyramidal neurons discharge from active phases of slow oscillations. (src: Nichols2016)
Cortical rhythms carry priors via predictive processing